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Multivariate regression analysis of postoperative complications of resection of hepatocellular carcinoma.

??Objective:To study the factors associated with postoperative complications of resection of hepatocellular carcinoma. Methods:Consecutive 378 cases of hepatocellular carcinoma between June 1988 and April 2005 at Xiangya Hospital were summarized retrospectively.Single??variant and multivariate stepwise regression model were used to analysis the factors associated with postoperative complications of resection of hepatocellular carcinoma. Results:The overall morbidity rate and mortality rate were 17.7% and 1.3% respectively.Single??variant analysis showed that the age,pringle maneuver,intraoperative blood loss and blood transfusion were associated with postoperative complications.Furthermore,multivariate stepwise regression analysis revealed that the age,pringle maneuver,intraoperative blood loss and blood transfusion volume were the independent risk factors of morbidity rate of resections of hepatocellular carcinoma. Conclusion:The surgical excisions of hepatocellular carcinomas are safe and feasible only if the liver function reserve could be judged accurately before operation and the intraoperative hemorrhage and blood transfusion could be controlled effectively and the duration of portal clamping could be shortened during the operation.