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High risk factors of intramammary lymphatic metastasis in breast cancer patients received extended radical mastectomy:an analysis of 1679 cases.

??Objective:To study the high risk factors of intramammary lymphatic metastasis in breast cancer patients received extended radical mastectomy. Methods:The clinical data of 1679 breast cancer patients received extended radical mastectomy between 1956 and 2003 in the Cancer Hospital of Fudan University was analyzed retrospectively.Four individual variables, such as patient age, tumor size, tumor site and axillary nodes metastasis status,were selected to investigate high risk factors of the intramammary lymphatic metastasis in different conditions. Results:Tumor size was not a independent predictor of intramammary lymphatic metastasis. Axillary node status was an important predictor of intramammary lymphatic metastasis.Tumor site and age had different effects on intramammary lymphatic metastasis in different conditions.The incidence of intramammary lymphatic metastasis is 4.4%,18.8%,28.1%,41.5% for patients with negative axillary nodes,1 to 3 positive axillary nodes,4-6 positive axillary nodes,7 or more positive axillary nodes,respectively. Conclusion:Four or more positive axillary nodes, internal tumor and positive axillary nodes,young patients with tumor greater than 5.0cm were high risk factors of intramammary lymphatic metastasis.