顺铂双路疗法在晚期口腔鳞癌治疗中的作用

目的 研究顺铂双路化疗在晚期口腔鳞癌治疗中的作用。方法 采用颈外动脉插管灌注顺铂、平阳霉素及５－氟脲嘧啶，同时静脉滴注硫代硫酸钠解毒的方法治疗晚期口腔鳞癌２３例，连续使用５－７ｄ为一疗程，顺铂的总剂量达１５０ｍｇ以上时进行疗效判断。结果 除１例因插管后出现暂时性肢瘫拒绝化疗，１例顺铂剂量不足１５０ｍｇ外，特效７例、显效１１例、无效３例（肿瘤缩小不足５０％），总有效率８５．７％。除Ⅰ～Ⅱ级的胃肠道反

The Use of Two-Route Cisplatin Chemotherapy in the Treatment of Oral Squamous Cell Carcinoma

OBJECTIVE: To study the feasibility and efficacy of two-route cisplatin chemotherapy for locally advanced squamous cell carcinoma of oral cavity. METHODS: 23 cases with clinical advanced biopsy-proven oral squamous cell carcinoma received intraarterial chemotherapy with cisplatin (DDP), Pingyangmycin (PYM) and 5-fluorouracilum (5-Fu), at the same time intravenous infusion with natrii thiosulfas (STS) for rescue. DDP at 40-60 mg/d, PYM at 16 mg/d and 5-Fu at 500 mg/d were applied for 5-7 consecutive days. RESULTS: 7 cases (33.3%) obtained a complete response (CR), 11(52.4%) had partial response (PR) with an objective response rate (RR) of 85.7%. No severe toxicity was observed, whereas the most frequent grade I and II drug related toxicities were nausea and vomiting. No nephrotoxicity,hepatotoxicity and severe bone marrow suppression were noted. CONCLUSION: Two-route cisplatin chemotherapy is, in our experience,a new,effective and safe therapeutic method for oral squamous cell carcinoma.