水蔓菁中黄酮类化合物的研究

从民间草药玄参科植物水蔓菁Veronica linariifolia Pall. ex Link. sub dilatata(Nakai et Litagawa)Hong.]的干燥全草的乙醇提取物中分离得到三个黄酮甙和两个黄酮甙元,其中甙Ⅰ是新化合物,命名为水蔓菁甙(linariifolioside)。根据光谱数据和水解产物分析确定甙Ⅰ的结构为木犀草素-7-O-6″′-O-乙酰基-β-D-葡萄糖基-(1→2)-β-D-葡萄糖甙luteolin-7-O-6″′-O-acetyl-β-D-glucosyl-(1→2)-β-D-glucoside]。另外甙Ⅱ,甙Ⅲ以及两个甙元为已知物,分别为木犀草素-7-O-β-D-葡萄糖基(1→2)-β-D-葡萄糖甙luteolin-7-O-β-D-glucosyl(1→2)-β-D-glucoside,Ⅱ]和芹黄素-7-O-x-L-鼠李糖甙(apigenin-7-O-α-L-rhamnoside,Ⅲ)、以及木犀草素(luteolin,Ⅳ)和芹黄素(apigenin,Ⅴ)。这些化合物在水蔓菁中均是首次得到。

STUDIES ON CHEMICAL CONSTITUENTS OF VERONICALINA RIIFOLIA PALL.EX LINK.SUB.DILATATA (NAKAI ET KITAGAWA) HONG.

A new flavonoid glycoside, named linariifolioside, C29H32O17 with mp at 232-234 degrees C (dec.), was isolated from the alcohol extract of the dried whole herb of Veronica linariifolia Pall. ex Link sub. dilatata (Nakai et Kitagawa) Hong. Based on spactral (IR, UV, 1HNMR, 13CNMR and FAB-MS) analysis and hydrolysis products its structure was identified as luteolin-7-O-6"'-O-acetyl-beta-D-glucosyl-(1----2)-beta-D-glucoside (I). In addition, four known compounds, luteolin-7-O-beta-D-glucosyl-(1----2)-beta-D-glucoside (II), apigenin-7-O-alpha-L-rhamnoside (III), luteolin (IV), and apigenin (V) were isolated from the same fraction and identified. These compounds were obtained for the first time from this plant.