利培酮对首发精神分裂症患者整夜睡眠脑电活动的影响

目的应用多导睡眠图(PSG)探讨利培酮对首发精神分裂症患者睡眠脑电活动的影响。方法 25例患者连续进行4夜 PSG 描记,其中第3、4晚睡前予1.2 mg 利培酮,观察用药后 PSG的变化。结果患者组服用利培酮后夜间睡眠总时间增加(基线睡眠值378 min±30 min,第3晚服药后406 min±34 min,第4晚服药后427 min±31 min,F=34.762,P<0.01),睡眠效率提高(基线睡眠值86%±10%,第3晚服药后90%±10%,第4晚服药后93%±12%,F=3.215,P<0.05),觉醒时间减少(基线睡眠值34 min±17 min,第3晚服药后23 min±15 min,第4晚服药后19 min±8 min,F=7.459,P<0.01),S_1阶段减少(基线睡眠值22%±10%,第3晚服药后15%±9%,第4晚服药后18%±9%,F=4.12,P<0.05),S2阶段增加(基线睡眠值54%±16%,第3晚服药后56%±18%,第4晚服药后65%±11%,F=3.484,P<0.05)。而睡眠潜伏期和慢波睡眠(SWS)尚未见明显变化。结论利培酮能改善睡眠质量。

Effects of risperidone on polysomnography in patients with first-episode schizophrenia

OBJECTIVE: To investigate the effects of risperidone on the polysomnography (PSG) in the patients with first-episode schizophrenia. METHODS: Twenty-five patients with first-episode schizophrenia, 13 males and 12 females, aged 29 +/- 8, underwent polysomnographic recording for 4 consecutive nights, the first night being used for acclimatization, and on the 3 rd and 4 th nights risperidone in the dose of 1.2 mg was administered before going to bed. Forty-four healthy persons, 23 males and 21 females, aged 28 +/- 8, underwent polysomnographic recording for 2 consecutive nights, the first night being used for acclimatization. RESULTS: The baseline PSG recording showed that in comparison with the normal control group the total sleep time of the schizophrenia patients was shorter (378 min +/- 30 min vs 462 min +/- 21 min), sleep latency was longer (30 min +/- 14 min vs 18 min +/- 8 min), rapid eye movement (REM) sleep latency was shorter (59 min +/- 20 min vs 88 min +/- 10 min), REM sleep time was shorter (61 min +/- 17 min vs 84 min +/- 12 min), awakening time was longer (34 min +/- 17 min vs 15 min +/- 5 min), stage 1 (S1) time was longer (22% +/- 10% vs 9.0% +/- 1.7%), S3 time and S4 time were shorter, and the sleep efficacy was lower (86% +/- 10%) (P < 0.05 approximately P < 0.01); however, there was no significant difference in the S2 time between these 2 groups (54% +/- 16% vs 56% +/- 4%, P > 0.05). In the schizophrenia group, in comparison with the baseline levels in the third and fourth nights the total sleep times were significantly increased (406 min +/- 34 min and 428 min +/- 31 min respectively), the awakening times were significantly decreased (23 min +/- 15 min and 19 min +/- 8 min respectively), and S1 times were significantly decreased (14 min +/- 9 min and 10 min +/- 9 min respectively), with such changes time-dependently; and in the 4 th night the REM sleep time was significantly increased (87 min +/- 20 min) and the sleep efficacy was significantly improved (93% +/- 12%) (P < 0.05 approximately P < 0.01), however, there were no significant differences in the sleep latency and slow wave sleep (both P > 0.05). CONCLUSION: Risperidone significantly improves the quality of sleep.