Angular and fibrous particles in lung in relation to silica-induced diseases |
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| Authors: | A Dufresne R Bégin C Dion J Jagirdar W N Rom P Loosereewanich D C F Muir A C Ritchie G Perrault |
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| Institution: | (1) McGill University, Department of Occupational Health, Faculty of Medicine, 3450 University Street., Suite 22, Montréal, (Québec H3A 2A7, Canada Tel: 514-398-8419; Fax: 514-398-8367 E-mail: cydu@musica.mcgill.ca, CA;(2) Service de pneumologie, Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada, CA;(3) Institut de recherche en santé et sécurité du travail, Direction des laboratoires, 505 Ouest, de Maisonneuve, Montréal, Québec H3A 3C3, Canada, CA;(4) Bellevue NYU Medical Centre, 27th Street-1st Avenue, New York, NY 10016, USA, US;(5) McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada, CA |
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| Abstract: | Introduction: The lung concentration of angular and fibrous particles was measured in cases of lung fibrosis only, in cases of lung fibrosis
and lung cancer, and in cases of lung cancer only. These patients worked in different trades (mining, foundries, construction
and were not a homogeneous group of exposed workers. Material and methods: Particles, both angular and fibrous, were extracted from lung parenchyma by a bleach digestion method, mounted on copper
microscopic grids by a carbon replica technique, and analyzed by transmission electron microscopy (TEM) and energy-dispersive
spectroscopy (EDS). The quartz concentration was also determined by X-ray diffraction (XRD) on a silver membrane filter after
extraction from the lung parenchyma. Results: (1) Lung cancer and lung fibrosis cases retained more metal-rich particles (P=0.02) and more angular particles of all sorts (P=0.009) than did lung fibrosis cases only, and the differences were statistically significant. (2) However, more quartz was
retained in the lungs in lung fibrosis cases than in lung fibrosis or lung cancer cases, but the difference in the concentrations
was not statistically significant. (3) More ferruginous bodies were retained in the lungs in lung cancer and lung fibrosis
cases than in cases of lung fibrosis only, and the difference in the concentrations was statistically significant (P=0.02). Conclusion: Results obtained from lung tissue must always be interpreted cautiously. However, these results are consistent with the hypothesis
that workers in some trades such as foundries were exposed not only to quartz but also to asbestos, ceramic fibers, metal-rich
non fibrous particles, and other likely carcinogenic chemicals. The wide range of particle types identified in the lungs of
these workers illustrates the complexity of trying to determine disease origins in these work environments. Epidemiology studies
have to control for the exposure to these carcinogens as well as for smoking habits.
Received: 8 April 1997 / Accepted: 11 December 1997 |
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| Keywords: | Angular and fibrous particles Silica Lung cancer TEM-EDS |
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