| 脐血血浆增强阿糖胞苷抗白血病效应的实验研究 |
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| 引用本文： | 张学忠,陈玉心,王秀华.脐血血浆增强阿糖胞苷抗白血病效应的实验研究[J].中华血液学杂志,1999,20(5):229-231. |
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| 作者姓名： | 张学忠 陈玉心 王秀华 |
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| 作者单位： | 南京医科大学附属南京第一医院血液科，南京医科大学第一附属医院血液科 |
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| 摘 要： | 目的研究脐血血浆（ＣＢＰ）对２８例急性髓系白血病（ＡＭＬ）细胞体外对阿糖胞苷（ＡｒａＣ）敏感性的影响。方法以基因重组人粒巨噬细胞集落刺激因子（ｒｈＧＭＣＳＦ）和空白组作对照，采用ＭＴＴ法检测ＡｒａＣ的细胞毒作用。结果ＡＭＬ细胞对ＡｒａＣ的敏感性表现出异质性，但使用ＣＢＰ及ｒｈＧＭＣＳＦ均可显著增强ＡｒａＣ对耐药ＡＭＬ细胞的毒性，与空白对照组相比，差异有显著性（Ｐ＜００５），尤以ＣＢＰ为优。结论ＣＢＰ与ｒｈＧＭＣＳＦ类似，可能通过促进耐药ＡＭＬ细胞进入增殖周期，从而增强ＡＭＬ细胞对ＡｒａＣ的敏感性，预示ＣＢＰ与ＡｒａＣ联合运用治疗耐药ＡＭＬ的潜在价值。
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| 关 键 词： | 胎血 血浆 白血病 阿糖胞苷 |
Experimental study of cord blood plasma enhancing the antileukemia effect of AraC |
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| ZHANG
Xuezhong,CHEN Yuxin,WANG Xiuhua,et al..Experimental study of cord blood plasma enhancing the antileukemia effect of AraC[J].Chinese Journal of Hematology,1999,20(5):229-231. |
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| Authors: | ZHANG
Xuezhong CHEN Yuxin WANG Xiuhua |
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| Institution: | Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006. |
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| Abstract: | Objective To study the in vitro effect of
cord blood plasma(CBP) on the sensitivity of acute myeloid leukemia(AML) cells to cytosine
arabinoside (AraC). Methods Cytotoxicity of AraC was detected by MTT assay in twentyeight
patients. Results and Conclusion The sensitivity of AML cells to AraC was heterogeneous,but
CBP could significantly enhanced the cytotoxic activity of AraC to drug resistant AML cells. |
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| Keywords: | Cord bloodPlasmaLeukemiaCytosine arabinoside |
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