白细胞介素-11预防和治疗头颈部肿瘤放疗导致口腔黏膜反应的疗效观察

目的 探讨预防和治疗头颈部肿瘤放疗性口腔黏膜反应的有效方法.方法 对2008年3月至2010年3月间50例头颈部肿瘤放疗患者随机分组对照观察.在放射治疗期间,观察组给予白细胞介素-11(IL-11)局部雾化吸入,对照组未给予IL-11.结果 观察组患者对IL-11耐受性良好,并在降低口腔黏膜反应程度、减轻疼痛和增进患者食欲等方面效果显著(P<0.05).患者的疼痛时间由对照组的4.5 d±1.3 d减为观察组的2.3 d±1.0 d,愈合时间由对照组的7.3 d±1.5 d减为观察组的4.1 d±1.7 d,差异有统计学意义(P<0.05).结论 IL-11对预防和治疗头颈部肿瘤放疗性口腔黏膜反应有显著疗效,可减轻放疗性口腔黏膜反应给患者带来的痛苦,提高了生活质量.

Effect of IL-11 in prevention and treatment of oral mucosal complications of radiotherapy for head and neck cancer

Objective To explore an effective method for preventing and treating oral mucosal complications of radiotherapy for head and neck cancer. Methods Fifty head and neck cancer patients who were receiving radiotherapy were enrolled between March, 2008 and March, 2010. These patients were randomly assigned to the treatment group and the control group. During the radiotherapy, patients in the treatment group were given IL-11 in the form of atomization inhalation,whereas patients in the control group were not. Results IL-1 1 was well tolerated by the patients. It significantly decreased the level of oral mucosal complications and pains and improved patients' appetites ( P < 0.05 ). In addition, the duration of pain was significantly ( P <0.05 ) reduced from 4.5 ± 1.3 days ( in control group) to 2.3 ± 1.0 ( in treatment group), and the healing period was also significantly ( P < 0.05) reduced from 7.3 ± 1.5 days ( in control group) to 4.1 ± 1.7 ( in treatment group). Conclusion IL-11 is effective in preventing and treating oral mucosal complications of radiotherapy for head and neck cancer,relieving associated pains, and therefore improving patients' quality of life.