布洛芬缓释微球的释放性能及体内外相关性研究

目的以壳聚糖及海藻酸钠为载体制备布洛芬缓释微球。方法对微球的体外释放特性、体内药物动力学及体内外相关性进行研究。结果布洛芬缓释微球体外药物释放行为符合Higuchi方程；与普通片剂相比，体内药代动力学中布洛芬缓释微球的达峰时间及半衰期延长，达峰浓度降低，生物利用度提高。结论所制布洛芬缓释微球达到了缓慢释放药物的目的，并且布洛芬缓释微球的体内外参数间有明显的相关性。

Study on Release of Ibuprofen Sustained- release Microsphere and Their in Vitro- in Vivo Correlation

Objective To prepare the suitable sustained-release microsphere containing ibuprofen using chitosan and sodium alginate as carriers.Methods The release characteristics in vitro,pharmacokinetics of ibuprofen microsphere in vivo,and their in vitro-in vivo correlation were evaluated.Results The drug releasing data in vitro showed that the release followed Higuchi equation.Ibuprofen commercial tablets were used as reference to study the pharmacokinetics of ibuprofen sustained release microsphere in vivo.tmax and t1/2 were prolonged,Cmax was reduced and F was raised.Conclusion Ibuprofen can achieve sustained release.There is a significant correlation between the dissolution in vitro and the absorption in vivo of ibuprofen sustained-release microsphere.