| 活化白细胞黏附分子在IgA肾病中的表达及意义 |
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| 引用本文： | 詹林达,邹循亮. 活化白细胞黏附分子在IgA肾病中的表达及意义[J]. 中国中西医结合肾病杂志, 2006, 7(8): 400-402 |
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| 作者姓名： | 詹林达 邹循亮 |
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| 作者单位： | 1. 中山大学附属第一医院肾内科,广州,510080;广东省中山市人民医院肾内科,中山,528400
2. 中山大学附属第一医院肾内科,广州,510080 |
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| 基金项目： | 广东省医药卫生科研项目 |
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| 摘 要： | 目的:探讨活化白细胞黏附分子(CD166)在IgA肾病中的表达及与IgA肾病临床病理特征的关系.方法:用免疫组化二步法检测CD166蛋白在79例IgA肾病患者肾组织的表达.结果:CD166在IgA肾病患者肾小管、间质普遍表达,按Lee分级的级别增加逐渐增高.与单纯性血尿患者(A组)相比,混合蛋白尿、血尿患者(B组)肾小管间质CD166表达明显增高.肾小管间质CD166表达与患者病理分级、小管间质病变、单个核细胞浸润程度及血清C反应蛋白(CRP)水平正相关.结论:CD166在IgA肾病中表达异常,在IgA肾病小管、间质病变及疾病进展中起一定作用.
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| 关 键 词： | 活化白细胞黏附分子 IgA肾病 蛋白尿 |
| 收稿时间： | 2005-12-29 |
| 修稿时间： | 2006-03-31 |
Expression and Potential Role of Activated Leukocyte Cell Adhesion Molecule in IgA Nephropathy |
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| ZHAN Linda,ZOU Xunliang. Expression and Potential Role of Activated Leukocyte Cell Adhesion Molecule in IgA Nephropathy[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2006, 7(8): 400-402 |
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| Authors: | ZHAN Linda ZOU Xunliang |
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| Abstract: | Objective:To investigate the expression of activated leukocyte cell adhesion molecule(ALCAM,namely CD_(166)) protein in IgA nephropathy(IgAN) and the relationship between CD_(166) expression and the clinicopathological features of IgAN.Methods:CD_(166) protein expression was evaluated in renal tissues of 79 patients with IgAN by using immunohistochemistry(Polymer Detection System).Results:CD_(166) was widely expressed in renal tubules and interstitium.Overexpression of CD_(166) was found in the interstitium with severe pathological changes in contrast to area with minimal pathological changes.The CD_(166) protein expression in IgAN was correlated with pathological grading,infiltrated mononuclear cells in renal interstitium and serum C-reactive protein.Conclusion:Expression of CD_(166) is abnormal in IgAN and might play roles in renal tubulo-interstitial lesion and disease progression. |
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| Keywords: | Activated leukocyte cell adhesion molecule(CD_(166)) IgA nephropathy Protienuria |
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