| 西罗莫司替换钙调磷酸酶抑制剂治疗老年亲属供肾移植受者移植肾功能减退的疗效 |
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| 引用本文： | 丰贵文,李金锋,王跃,庞新路,尚文俊,刘磊.西罗莫司替换钙调磷酸酶抑制剂治疗老年亲属供肾移植受者移植肾功能减退的疗效[J].器官移植,2011,2(4):194-196. |
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| 作者姓名： | 丰贵文 李金锋 王跃 庞新路 尚文俊 刘磊 |
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| 作者单位： | 郑州大学第一附属医院肾移植科,450052 |
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| 基金项目： | 郑州市科技局基金资助项目(083SGYS33263-4) |
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| 摘 要： | 目的 观察西罗莫司替换钙调磷酸酶抑制剂(CNI)治疗老年亲属供肾移植受者移植肾功能减退的临床效果.方法 选择病理检查证实为CNI药物肾毒性(11例)和慢性移植肾肾病(chronic allograft nephropathy,CAN)(13例)并出现慢性移植肾功能减退的24例老年亲属供肾肾移植受者,将原有免疫抑制方案环...
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| 关 键 词： | 肾移植 西罗莫司 钙调磷酸酶抑制剂 环孢素 他克莫司 |
Effect of conversion from calcineurin inhibitors to sirolimus for renal function deterioration in living-related renal transplantation from elderly donors |
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| FENG Gui-wen,LI Jin-feng,WANG Yue,PANG Xin-lu,SHANG Wen-jun,LIU Lei.Effect of conversion from calcineurin inhibitors to sirolimus for renal function deterioration in living-related renal transplantation from elderly donors[J].Ogran Transplantation,2011,2(4):194-196. |
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| Authors: | FENG Gui-wen LI Jin-feng WANG Yue PANG Xin-lu SHANG Wen-jun LIU Lei |
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| Institution: | FENG Gui-wen,LI Jin-feng,WANG Yue,PANG Xin-lu,SHANG Wen-jun,LIU Lei.Department of Renal Transplantation,First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To observe the clinical effect of conversion from calcineurin inhibitors(CNI)to sirolimus for renal function deterioration in living-related renal transplantation from elderly donors.Methods Twenty-four recipients with renal function deterioration in living-related renal transplantation from elderly donors were selected,in which 11 cases were proven to be CNI induced renal toxicity by pathology and another 13 cases were chronic allograft nephropathy(CAN).The immunosuppression was converted from ci... |
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| Keywords: | Renal transplantation Sirolimus Calcineurin inhibitors Ciclosporin Tacrolimus |
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