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Human herpesvirus‐6 encephalitis following chemotherapy induction for acute myelogenous leukemia
Authors:John W. Frey  Joseph N. Cherabie  Maha A. Assi
Affiliation:1. Kansas City University of Medicine and Biosciences, Kansas City, MO, USA;2. Department of Internal Medicine, University of Kansas School of Medicine – Wichita, Wichita, KS, USA;3. Department of Infectious Disease, University of Kansas School of Medicine – Wichita, Wichita, KS, USA
Abstract:We report a case of human herpesvirus‐6 (HHV‐6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad‐spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Electroencephalogram and magnetic resonance imaging of the brain were unremarkable. Following diagnosis, the patient was successfully treated with ganciclovir. HHV‐6 encephalitis should be considered in immunocompromised patients who become encephalopathic.
Keywords:acute myelogenous leukemia  encephalitis  human herpesvirus‐6  immunocompromised
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