Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence |
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| Authors: | P N Filimonov T G Sukhenko A N Papantonopulo N I Gavrilova V A Shkurupii |
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| Institution: | (1) Novosibirsk State Medical Academy, Russia;(2) Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Russia;(3) Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Russia |
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| Abstract: | Young and middle-aged CBA mice were injected with “street” heroin in increasing doses for 14 days. Volume density of perisinusoid
argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels
of spontaneous, LPS-and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation
further progress of liver fibrosis was observed in young mice.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 140, No. 12, pp. 678–680, December, 2005
Municipal Clinical Hospital No. 12 |
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| Keywords: | heroin liver fibrosis age |
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