Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study |
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| Authors: | N. Siitonen L. Pulkkinen U. Mager J. Lindström J. G. Eriksson T. T. Valle H. Hämäläinen P. Ilanne-Parikka S. Keinänen-Kiukaanniemi J. Tuomilehto M. Laakso M. Uusitupa |
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| Affiliation: | (1) Department of Public Health and Clinical Nutrition, Clinical Nutrition, and Food and Health Research Centre, University of Kuopio, Kuopio, Finland;(2) Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland;(3) Research Department, Social Insurance Institution, Turku, Finland;(4) Finnish Diabetes Association and Tampere University Hospital Research Unit, Tampere, Finland;(5) Department of Public Health Science and General Practice, Oulu University Hospital, University of Oulu, Oulu, Finland;(6) Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland;(7) Department of Public Health, University of Helsinki, Helsinki, Finland;(8) South Ostrobothnia Central Hospital, Seinäjoki, Finland;(9) Department of Medicine, University of Kuopio, Kuopio, Finland |
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| Abstract: | Aims/hypothesis Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the association of ADIPOR1 gene variations with body size and risk of type 2 diabetes in subjects with impaired glucose tolerance, who participated in the Finnish Diabetes Prevention Study (DPS).Subjects and methods We selected seven single nucleotide polymorphisms (SNPs) of the ADIPOR1 gene to perform association studies with anthropometrics and metabolic parameters at baseline, and with the risk of type 2 diabetes during the 3-year follow-up in the DPS study population. Both single SNP analysis and haplotype effects were studied.Results Three out of seven markers studied (rs10920534, rs22757538 and rs1342387) were significantly associated with various body size measurements including weight, height, waist and hip circumference, sagittal diameter and body mass index. Furthermore, three markers (rs10920534, rs12045862 and rs7539542), of which two were different from those associating with body size, were linked to fasting and 2-h insulin levels, particularly in men at baseline. The haplotype analysis with five markers revealed seven major haplotypes in the DPS study population. The haplotype effects on body size measures were in line with those of single SNP analysis. However, none of the markers were associated with the risk of type 2 diabetes.Conclusions/interpretation Our findings suggest that ADIPOR1 has a putative role in the development of body size, and that traits for central adiposity and insulin resistance may be dissociated from each other.Electronic Supplementary Material Supplementary Material is available in the online version of this article at |
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| Keywords: | Adiponectin Adiponectin receptor Adiposity Body size Genetic variation Type 2 diabetes |
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