Present state and prospects of adjuvant chemotherapy for gastric cancer |
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Authors: | Hori Takaaki Ozawa Rie Hanayama Hiroyuki Yamashita Hidetaka Kaibe Noriaki Matsumoto Tomohiro Oshima Tsutomu Takemura Masashi Kikuchi Shojiro Sasako Mitsuru |
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Affiliation: | Upper GI Surgery Division, Dept. of Surgery, Hyogo College of Medicine. |
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Abstract: | In Japan, a one-year administration of S-1 is the standard adjuvant treatment for stage II/III gastric cancer after curative gastrectomy with a D2 lymph-node dissection.The treatment is recommended in the Japanese Guidelines for Treatment of Gastric Cancer(3rd Edition).Using data from results of a 5-year follow-up of the ACTS-GC trial, it was confirmed that using S-1 significantly improves the 5-year overall survival over surgery alone.However, the recurrence rate of stage III gastric cancer is still too high.More powerful treatment using multiple drugs is needed for this disease.This paper presents a new perspective for the development of post-operative adjuvant chemotherapy in the future, based on clinical trials recently reported. |
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