高同型半胱氨酸血症与短暂性脑缺血发作的相关性

目的探讨高同型半胱氨酸血症（HHcy）与短暂性脑缺血发作（TIA）的相关性。方法对80例TIA患者（40例颈内动脉系统TIA、40例椎-基底动脉系统TIA）和40例健康者进行血浆Hcy及血脂检测。结果颈内动脉系统TIA和椎-基底动脉系统TIA患者的Hcy水平均高于对照组,差异有显著性（P〈0.05）,且两者之间比较亦有显著性差异（P〈0.05）。结论血浆Hcy水平与TIA有关,且与颈内动脉系统TIA关系更加密切,是TIA的独立危险因素。

Study on the Relationship Between Hyperhomocysteinemia and TIA

Objective To investigate the relationship between Hyperhomocysteinemia(HHcy) and transient ischemic attacks(TIA).Methods Plasm Hcy and blood-lipid were tested in 80 patients with TIA(40 patients in TIA were caused by internal carotic artery System and the other 40 ones were caused by vertebro-basilar artery system) and 40 healthy people only for physical examination.Results The patients is TIA by internal carotid artery System or vertebro-basilar artery system had higher standards of plasm concentration of Homocysteine than the control group(P<0.05).The standards of plasm concentration of Homocysteine in the patients in TIA by internal carotid artery System are significantly different from the ones in TIA by vertebro-basilar artery system(P<0.05).Conclusion There is an association between plasm concentration of Hcy and TIA,and TIA by internal carotid artery is more significantly correlated.There is no association between the level of plasma Hcy and blood-lipid.Plasma Hcy can be one of the independent risk factors for TIA.