高强度聚焦超声治疗晚期胰腺癌17例临床疗效分析

目的观察高强度体外聚焦超声(HIFU)治疗晚期胰腺癌的安全性及近期疗效。方法应用FEP-BYO2肿瘤超声治疗机治疗胰腺癌17例,共接受治疗135次(平均每例8次)。结果完全缓解率(CR)11.76%(2/17),部分缓解率(PR)58.82%(10/17),总有效率70%(CR PR)。临床受益反应率(CBR)82.36%,无效率17.64%(3/17)。癌性疼痛缓解率80%(8/10)。所有病例治疗时均未出现胰液外漏、腹腔内出血、胃肠道损伤等相关并发症。结论HIFU治疗晚期胰腺癌能取得一定的疗效,治疗安全性高,值得临床进一步观察研究。

A Clinical Study on High Intensity Focused Ultrasound Treating 17 Cases with Advanced Pancreatic Carcinoma

Objective To evaluate the recent curative efficacy and security of High Intersity Focused Ultrasound(HIFU)in treating patients with advanced pancretic carcinoma.Methods 17patients with cancer of pancreas were treated by FEP-BY02,received 135(average 8)times.Results The overall response rate was 70%(CR PR),including11.76%(2/17)complete response(CR)and 58.82%(10/17)partial response(PR).The clinical benefit response(CBR)was 82.36%.The inefficiency was 17.64%(3/17).The cancer pain was relieved in 80% patients(8/10).Nocomplications occurred.such as pancreatic juice leakage,bleeding,perforation of gastrointestinal tracts,scalding of skin in the group.Conclusions The preliminary results show that HIFU has a high efficacy and quite safety for advanced pancreatic carcinoma,it is worthy of futher clinical trail.