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| Ets-1在链脲左菌素诱导的糖尿病大鼠模型视网膜内表达增强 | |
| 引用本文： | 杜兆江,李鹏,惠延年,王百忍,段小莉,张瑞.Ets-1在链脲左菌素诱导的糖尿病大鼠模型视网膜内表达增强[J].国际眼科杂志,2007,7(1):19-22. |
| 作者姓名： | 杜兆江 李鹏 惠延年 王百忍 段小莉 张瑞 |
| 作者单位： | 1. 710032,中国陕西省西安市,第四军医大学西京医院眼科 2. 710054,中国陕西省西安市,解放军第451医院眼科 3. 710032,中国陕西省西安市,第四军医大学全军神经生物研究所 4. 710038,中国陕西省西安市,第四军医大学唐都医院药剂科 |
| 摘 要： | 目的:阐明Ets-1是否参与了实验性糖尿病视网膜病变过程.方法:腹腔注射链脲左菌素(STZ)来诱导糖尿病.STZ注射后4 wk,分离各组视网膜内总RNA和总蛋白,分别进行Northern blot和Western blot分析.结果:实验性糖尿病视网膜内Ets-1在mRNA水平和蛋白水平均明显高于对照组(P＜0.001).结论:实验结果表明Ets-1参与了实验性糖尿病视网膜的病理过程.进一步研究需要阐明Ets-1和VEGF关系. |
| 关 键 词： | Ets-1 VEGF 糖尿病视网膜 新生血管 Ets-1 VEGF diabetic retina angiogenesis 菌素 病大鼠模型 视网膜内 表达 增强 rat model retina expression studies focus relationship group Expression proteins increased RESULTS Total isolated control eyes |
| 文章编号： | 23819859 |
| 修稿时间： | 01 27 2007 12:00AM |
Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model |
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| Zhao-Jiang Du,Peng Li,Yan-Nian Hui,Bai-Ren Wang,Xiao-Li Duan,Rui Zhang.Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model[J].International Journal of Ophthalmology,2007,7(1):19-22. | |
| Authors: | Zhao-Jiang Du Peng Li Yan-Nian Hui Bai-Ren Wang Xiao-Li Duan Rui Zhang |
| Abstract: | AIM: To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina. METHODS: Diabetes was induced by intraperitoneal injection of STZ. Total RNA and Total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively.RESULTS: Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P＜0.001).CONCLUSION: Our results indicated that Ets-1 was involved in the pathological progress of experimental diabetic retina.Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina. |
| Keywords: | Ets-1 VEGF diabetic retina angiogenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |