| 庆大霉素重组合异种骨在犬肢体Ⅲb炸伤中抗感染的实验研究 |
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| 引用本文： | 张旭东,郭树忠,胡蕴玉,卢丙仑,张琳西,杨力,倪云志.庆大霉素重组合异种骨在犬肢体Ⅲb炸伤中抗感染的实验研究[J].中国骨与关节损伤杂志,2004,19(8):539-540. |
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| 作者姓名： | 张旭东 郭树忠 胡蕴玉 卢丙仑 张琳西 杨力 倪云志 |
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| 作者单位： | 第四军医大学第一附属医院整形外科中心,西安市,710032;第四军医大学第一附属医院骨科研究所 |
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| 摘 要： | 目的 探讨庆大霉素重组合异种骨复合体 (G -BRX)在犬四肢爆炸伤中抗感染能力。方法 炸伤试验犬左后肢。造成Ⅲb骨折 ,外固定架固定。 3d后取出骨折碎片 ,人为的造成一约 1 5cm× 1cm皮质骨骨缺损 ,分为两组 ,A组局部运用G -BRX10粒 ,B组为对照 ,运用自身骨碎片。两组局部均运用金葡菌 5× 10 6CFU ,而后用游离肌皮瓣覆盖创面。术后 6个月观察各组骨髓炎发生率。结果 A组仅有 1例感染 ,B组有 7例感染 ,二者有统计学差异。结论 庆大霉素重组异种骨复合体在爆炸伤创面的早期修复中可有效的防治感染 ,是骨缺损早期修复的一种良好材料。
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| 关 键 词： | 庆大霉素重组合异种骨 爆炸伤 肢体 骨髓炎 |
| 修稿时间： | 2004年1月13日 |
The Anti - infective Capability of Gentamicin - reconstituted Bone Xenograft - composite for Blasted Limb of Dog with Bone Defects |
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| Zhang Xudong,Guo Shuzhong,Hu Yunyu,et al..The Anti - infective Capability of Gentamicin - reconstituted Bone Xenograft - composite for Blasted Limb of Dog with Bone Defects[J].Chinese Journal of Bone and Joint Injury,2004,19(8):539-540. |
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| Authors: | Zhang Xudong Guo Shuzhong Hu Yunyu |
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| Institution: | Zhang Xudong,Guo Shuzhong,Hu Yunyu,et al.Department of Plastic Surgery,Xijing Hospital,The Fourth Military Medical University,Xi'an,710032 |
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| Abstract: | Objective To study the local anti-infective capability of gentamicin loaded recongstituted bone xenograft(G-RBX) which was utilized to repair the blasted bone defect.Methods A canine model of bone defect caused by detonator was repaired with G-RBX,Then the ratio of osteomyelitis after repair was studied with radiology,histology,germiculture.Results The infective ratio was remarkably lower in Group A than Group B.Conclusion G-RBX is a good grafts to blasted bone defect as a anti-infective stuff. |
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| Keywords: | G-BRX Blast would Osteomyelitis |
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