COX-2和EGFR在鼻咽癌组织中的表达及临床意义

目的探讨环氧合酶-2（COX-2）和表皮生长因子受体（EGFR）在鼻咽癌组织中的表达及临床意义。方法应用免疫组化EnVision两步法,检测111例鼻咽癌和20例正常鼻咽黏膜组织中COX-2和EGFR蛋白的表达。结果111例鼻咽癌组织中,COX-2和EGFR的阳性率分别为76.58%和73.87%,均明显高于正常对照组（P〈0.01）。COX-2和EGFR的表达均与原发肿瘤范围、淋巴结转移及临床分期关系密切,且两者之间呈正相关（rs=0.657,P〈0.01）。结论COX-2和EGFR与鼻咽癌的发生、发展有关,两者可能存在协同作用,可作为评估鼻咽癌进展和判断预后的重要指标。

Expression and clinical significance of cyclooxygenase-2 and epidemal growth factor in nasopharyngeal carcinoma

Objective To invetigate the expression of cyclooxygenase-2(COX-2),epidemal growth factor(EGFR) and their clinical significance in nasopharyngeal carcinoma(NPC). Methods The expression of COX-2 and EGFR was detected with immunohistochemical EnVision method in 111 cases of NPC and 20 cases of normal nasopharyngeal mucosa. Results Among 111 cases of NPC,the positive expression rates of COX-2 and EGFR were 75.68% and 73.87% respectively,higher than that in control group(P<0.01).The expression of COX-2 and EGFR in NPC was associated with the extent of primary lesion,lymph nodes metastasis and TNM stages(P<0.01).Expression of COX-2 was strongly correlated with the expression of EGFR(r_s =0.657,P<0.01). Conclusion COX-2 and EGFR have synergistic effects and may play an important role in the development and progression of NPC.The expression of COX-2 and EGFR may be useful biomarkes to assess clinical status and prognosis of patients with NPC.