New isoflavone glycosides from <Emphasis Type="Italic">Iris spuria</Emphasis> L. (Calizona) cultivated in Egypt |
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Authors: | Salwa F Farag Yuka Kimura Hideyuki Ito Junko Takayasu Harukuni Tokuda Tsutomu Hatano |
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Institution: | (1) Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt;(2) Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima Okayama, 700-8530, Japan;(3) Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, Japan |
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Abstract: | Two new isoflavone glycosides, tectorigenin 7-O-β-d-glucopyranoside-4′-O-β-d-glucopyranosyl-(1″″ → 6′′′)-β-d-glucopyranoside] (1) and iristectorigenin B 4′-O-β-d-glucopyranosyl-(1′′′ → 6″)-β-d-glucopyranoside] (2), together with 11 known compounds, including six isoflavones, tectorigenin 7-O-β-d-glucopyranoside-4′-O-β-d-glucopyranoside (3), tectorigenin 4′-O-β-d-glucopyranosyl-(1′′′ → 6″)-β-d-glucopyranoside] (4), tectorigenin 7-O-β-d-glucopyranoside (5), genistein 7-O-β-d-glucopyranoside (6), tectorigenin 4′-O-β-d-glucopyranoside (7), and tectorigenin (8); two phenolic acid glycosides, vanillic acid 4-O-β-d-glucopyranoside (9) and glucosyringic acid (10); a phenylpropanoid glycoside, E-coniferin (11); an auronol derivative, maesopsin 6-O-β-d-glucopyranoside (12); and a pyrrole derivative, 4-(2-formyl-5-hydroxymethylpyrrol-1-yl) butyric acid (13), were isolated from fresh Iris spuria (Calizona) rhizomes. The structures of these compounds were established on the basis of spectroscopic and chemical evidence.
Inhibitory effects on the activation of Epstein–Barr virus early antigen were examined for compounds 1–8 and 12. |
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Keywords: | Auronol Iridaceae Iris spuria Isoflavone glycosides Phenolic acid glycosides Phenylpropanoid glycoside |
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