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调节性T细胞在支气管哮喘中的重要作用
引用本文:许飞,林耀广. 调节性T细胞在支气管哮喘中的重要作用[J]. 基础医学与临床, 2004, 24(4): 371-374
作者姓名:许飞  林耀广
作者单位:中国协和医科大学,北京协和医院,北京,100005;中国协和医科大学,北京协和医院,北京,100005
摘    要:本文论述了调市性T细胞的概念及几种主要的调节性T细胞:Th1、Th2、Th3细胞、TR细胞、CD4^ CD25^ 细胞、NKT细胞的主要特点和研究现状。并论述了这儿种调节性T细胞在支气管哮喘中的重要作用。提出Th1细胞更趋向于一种炎症细胞而非抗炎细胞,而其他各种调节性T细胞可能提供免疫保护及抗炎作用起到抑制哮喘发展的作用,通过控制调节性T细胞的治疗可能成为哮喘治疗的有效手段。

关 键 词:调节性T细胞  支气管哮喘
文章编号:1001-6325(2004)04-0371-04
修稿时间:2004-06-15

The important role of regulatory T cells in asthma
XU Fei,LING Yao-guang. The important role of regulatory T cells in asthma[J]. Basic Medical Sciences and Clinics, 2004, 24(4): 371-374
Authors:XU Fei  LING Yao-guang
Abstract:The article discusses the concept of regulatory T cells(T R ) and the main characteristic and research status of several main T R cells: Th1,Th2,Th3 cells, T R cells, CD4 +CD25 + cells,NKT cells, and dissertate the important role of these regulatory T cells in asthma.It was showed that Th1 cell are generally proimflamtory cell rather than anti-imflamtory cell, Rather, a wide variety of regulatory T cells could probably control the development of asthma by protective imunuity or anti-imflamaory response. Therapies that control the development of regulatory T cells in patients with asthma may be very effective in the prevention and cure of these disorders.
Keywords:regulatory T cells  asthma  
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