| 血管新生及抗血管新生靶向治疗在神经纤维瘤中的研究进展 |
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| 引用本文： | 顾熠辉,任捷艺,李青峰,王智超.血管新生及抗血管新生靶向治疗在神经纤维瘤中的研究进展[J].中国临床医学,2019,26(6):931-935. |
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| 作者姓名： | 顾熠辉 任捷艺 李青峰 王智超 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院整复外科, 上海 200011,上海交通大学医学院附属第九人民医院整复外科, 上海 200011,上海交通大学医学院附属第九人民医院整复外科, 上海 200011,上海交通大学医学院附属第九人民医院整复外科, 上海 200011 |
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| 基金项目： | 上海市青年拔尖人才开发计划，上海交通大学医学院附属第九人民医院青年医师协同创新团队计划（QC201803）. |
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| 摘 要： | 神经纤维瘤是整复外科最常见的良性皮肤软组织肿瘤之一,但8%～13%存在恶变风险。研究提示血管新生对神经纤维瘤的进展和恶变起着重要的促进作用,而抗血管新生药物在神经纤维瘤的相关研究中也充分显示出潜在的临床应用价值。本文主要对神经纤维瘤的血供特点、血管新生机制以及抗血管新生靶向治疗的研究进展进行综述。
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| 关 键 词： | 神经纤维瘤 血管新生 治疗 |
| 收稿时间： | 2019/5/15 0:00:00 |
| 修稿时间： | 2019/6/24 0:00:00 |
Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma |
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| GU Yi-hui,REN Jie-yi,LI Qing-feng and WANG Zhi-chao.Angiogenesis and anti-angiogenesis targeted therapy in neurofibroma[J].Chinese Journal Of Clinical Medicine,2019,26(6):931-935. |
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| Authors: | GU Yi-hui REN Jie-yi LI Qing-feng and WANG Zhi-chao |
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| Institution: | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China,Department of Plastic and Reconstructive Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China,Department of Plastic and Reconstructive Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China and Department of Plastic and Reconstructive Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China |
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| Abstract: | Neurofibroma has been one of the most common clinical manifestations in neurofibromatosis type 1, among which about 8%-13% has risk of malignant transformation. Previous researches suggest that angiogenesis plays an important role in the progression and malignancy of neurofibroma, while the anti-angiogenesis drugs have also demonstrated their potential clinical value in neurofibroma. In this article, the blood supply characteristics of neurofibroma, the mechanism of angiogenesis, and the research progress of anti-angiogenesis targeted therapy in neurofibroma are reviewed. |
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| Keywords: | neurofibroma angiogenesis treatment |
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