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Chromosomal insertion involving MLL in childhood acute myeloblastic leukemia (M4) |
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| Authors: | Lafay-Cousin Lucie Soenen Valérie Mazingue Françoise Preudhomme Claude Laï Jean-Luc Andrieux Joris |
| Institution: | a INSERM Unité 524, Institut de Recherches sur le Cancer de Lille, 1 place de Verdun, 59000, Lille Cedex, France b Laboratoire d'Hématologie, Hôpital Calmette, CHRU, Lille Cedex, France c Laboratoire de Génétique Médicale, Hôpital Jeanne de Flandre, Barre Nord CHRU, 2 Avenue Oscar Lambret, 5309, Lille Cedex, France d Service d'Hématologie Pédiatrique, Hôpital Jeanne de Flandre, CHRU, 2 Avenue Oscar Lambret, 5309, Lille Cedex, France |
| Abstract: | Recurrent chromosomal rearrangements involving the 11q23 region have been described in various hematologic malignancies. Among these rearrangements, translocations are the most common mechanism involving the mixed lineage leukemia gene (MLL). Few cases of insertion have been reported and, to our knowledge, none of them involved MLL and chromosome 1. We report a complex karyotype in a childhood acute myelomonocytic leukemia (AML M4) involving the 11q23 region with an insertion between chromosomes 1 and 11 in addition to a translocation between chromosomes 11 and 22. This translocation was clarified by fluorescence in situ hybridization (FISH) analysis: 46,XY,ins(1;11)(q22 q23;q13q23),t(11;22)(q13;q11q12). This finding also underlines the complementary contribution of conventional cytogenetic and FISH analysis to detect karyotypic complex abnormalities. |
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