大肠癌代谢酶基因多态性的Meta分析

目的 综合评价代谢酶基因多态性与大肠癌危险性的关系。方法 应用Meta分析原理对国内42篇大肠癌相关代谢酶基因多态性的病例研究进行定量综合分析。统计处理采用M-H法或D-L法以及RevM4.1统计软件包。结果 GSTM1缺陷型，GSTT1缺陷型，GSTP1Llel105Val,NAT1*10,NAT2快速乙酰化表型/基因型，乙酰化表型，乙酰化基因型，CYP1A1MspI,CYP1A1Lle462Val,MTHFRC677T和MTRA2759G11个研究因素的综合统计量（OR值）分别为1.06,1.42,1.09,1.25,1.08,1.15,1.05,1.26,1.30,0.83和0.60。结论 GSTT1缺陷型，NAT2快速乙酰化表型/基因型和NAT2快速乙酰化表型可能与大肠癌的发生有关。

A Meta-analysis Study on Metabolizing Enzyme Polymorphisms of Colorectal Cancer

Objective To evaluate the relationship between genetic polymorphisms of metabolizing enzyme and colorectal cancer. Methods The results of 42 epidemiological studies from 1990 to 2001 were analyzed by means of Meta analysis. Mantel Haenszel fixed effects model, Dersimonian Lair random effects model and ReviewManager4 1 statistical program were applied in processing data. Results The pooled OR values of GSTM1 deletion, GSTT1 deletion, GSTP1 lle105Val, NAT1*10, NAT2 rapid acetylator phenotype&genotype, NAT2 rapid acetylator phenotype, NAT2 rapid acetylator genotype, CYP1A1 Lle462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G were 1 06, 1 42, 1 09, 1 25, 1 08, 1 15, 1 05, 1 26, 1 30, 0 83 and 0 60 respectively. Conclusions Genetic polymorphisms of colorectal cancer are significantly associated with the GSTT1 deletion, NAT2-rapid acetylator phenotype&genotype and NAT2-rapid acetylator phenotype.