| 神经干细胞、丙戊酸联合应用对成鼠脊髓损伤的修复作用 |
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| 引用本文： | 王莉,伍亚民,刘媛,南国新,曾琳. 神经干细胞、丙戊酸联合应用对成鼠脊髓损伤的修复作用[J]. 创伤外科杂志, 2009, 11(2): 159-162 |
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| 作者姓名： | 王莉 伍亚民 刘媛 南国新 曾琳 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所三室,创伤、烧伤与复合伤国家重点实验室,重庆,400042;第三军医大学大坪医院野战外科研究所三室,重庆,400042 |
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| 基金项目： | 国家自然科学基金，重庆市自然科学基金，校回国人员启动基金 |
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| 摘 要： | 目的观察神经干细胞（NSCs）和丙戊酸（VPA）联合应用对成年大鼠脊髓损伤后的修复作用。方法SD大鼠随机分为单纯损伤组、NSCs移植组和NSCs＋VPA治疗组。采用半切脊髓损伤模型，损伤后进行病理染色和神经诱发电位检测。结果NSCs＋VPA治疗组损伤处空洞闭合情况优于其余两组，移植物和宿主脊髓建立的纤维联系较其余两组多，排列有序。NSCs＋VPA治疗组诱发电位各项指标匀优于其余两组，8周时最显著，其中以运动诱发电位（MEP）的优化最明显。结论NSCs和VPA联合应用对成鼠脊髓损伤具有良好的修复作用。
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| 关 键 词： | 脊髓损伤 神经干细胞 丙戊酸 创伤修复 |
Effects of neural stem cell and valproic acid on the repair of spinal cord injury in adult rats |
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| WANG Li,WU Ya-min,LIU Yuan,et al.. Effects of neural stem cell and valproic acid on the repair of spinal cord injury in adult rats[J]. Journal of Traumatic Surgery, 2009, 11(2): 159-162 |
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| Authors: | WANG Li WU Ya-min LIU Yuan et al. |
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| Affiliation: | Department 3;State Key Laboratory of Trauma;Burns and Combined Wound;Institute of Surgery Research;Daping Hospital;Third Military Medical University;Chongqing400042;China |
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| Abstract: | Objective To observe the effects of neural stem cells(NSCs) and valproic acid(VPA)on the repair after spinal cord injury in adult rats.MethodsSD rats were divided into three groups randomly: the injury group,NSCs group and VPA+NSCs group.Models of hemi-sected spinal cord injury were established in all rats.Pathological staining and electrophysiology examination were taken to observe the repair effect.ResultsCavity closing in VPA+NSCs group was better than that of other two groups.Fiber connection between th... |
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| Keywords: | spinal cord injury neural stem cell valproic acid injury repair |
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