噪声对机体血清SOD和MDA表达水平的影响

目的探讨噪声对机体血清超氧化物歧化酶(SOD)和丙二醛(MDA)表达水平的影响。方法检测噪声暴露厂企业工人(噪声暴露组,n=80)和其他非噪声暴露企业工人(对照组,n=80)血清SOD和MDA表达水平,同时对两组工人进行纯音听阈测试。结果噪声暴露组工人接噪强度显著高于对照组(87.5±2.7)dB vs(82.2±2.4)dB](P<0.05);噪声暴露组血清SOD表达水平显著低于对照组(P<0.05),血清MDA表达水平明显高于对照组(P<0.05);两组语频听力与高频听力损失比较差异有统计学意义(P<0.05);血清中MDA与SOD表达水平呈负相关(P<0.05),与双耳高频听力损失呈正相关(P<0.05)。结论血清SOD表达水平对噪声所致机体氧化损伤有一定的保护作用。

The Effects of Noise on the Expression Levels of Serum SOD and MDA in Human Body

Objective To investigate the effects of noise on the expression levels of serum superoxide dismutase（ SOD ） and malondialdehyde （MDA） in human body. Methods The serum SOD and MDA expression levels in workers at noisy factory （noise exposure group, n = 80） and the others at non-noisy facto- ry（ control group ,n = 80 ） were investigated while sound hearing threshold test were performed for the two groups. Results The noise exposure intensity of the noise exposure group （87.5 ± 2.7 ） dB was significantly higher than that of the control group （ 82.2 ± 2.4） dB ; the serum SOD expression levels of the noise exposure group were significantly lower than those of the control group（ P 〈 0.05 ）, while the serum MDA levels of the noise exposure group were significantly higher than those of the control group （ P 〈 0.05 ） ; there was a significant difference between the two groups in speech frequency and high-frequency hearing loss（ P 〈 0.05 ） ; the serum levels of MDA was negatively correlated to SOD expression （P 〈 0.05 ）, but positively to binaural high-frequency hearing loss （ P 〈 0.05 ）. Conclusion Serum SOD expression level has a protective effect on oxidative damage caused by noise.