Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome |
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Authors: | Hassaballa Hesham A Lateef Omar B Silver Michael R Balk Robert A |
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Institution: | Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rush Medical College and Rush University Medical Center, Chicago, IL 60612, USA. hhassaba@rush.edu |
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Abstract: | Arsenic trioxide has been used successfully for the treatment of refractory acute promyelocytic leukemia and has shown promise in the treatment of myelodysplastic syndrome (MDS), although it is not a labeled indication. Retinoic acid syndrome is manifested by fever, dyspnea, peripheral edema, pulmonary infiltrates, and pleural and/or pericardial effusions and is typically seen in conjunction with all- trans retinoic acid therapy of acute promyelocytic leukemia. We report a case of acute lung injury and a retinoic acid syndrome-like illness in a patient who received arsenic for MDS. To our knowledge, this is the first such report, and clinicians should be aware of this potentially life-threatening complication of arsenic trioxide treatment in patients with MDS. |
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Keywords: | Retinoic acid syndrome Arsenic Myelodysplastic syndrome Cough Pulmonary infiltrates Pleural effusion Acute lung injury |
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