卡托普利联合胺碘酮治疗急性心肌梗死并发心房颤动的临床研究

目的 探讨卡托普利联合胺碘酮治疗急性心肌梗死并发心房颤动的疗效.方法 急性心肌梗死并发心房颤动62例分两组,治疗组予以卡托普利联合胺碘酮治疗,对照组予以普罗帕酮治疗,比较24h心房颤动转复率、心房颤动发作控制(减少心房颤动发作60%以上)率、充血性心力衰竭发生率、再梗死率、住院期间死亡率、1年后死亡率、1年内脑卒中发生率.结果 治疗组能控制心房颤动发作(减少心房颤动发作60%以上),维持窦性心律,与对照组相比,再梗死率(6.3%与16.7%)、死亡率(9.4%与16.7%)、充血性心力衰竭发生率(9.4%与30.0%)、脑卒中发生率(3.1%与13.3%),均明显降低(均P<0.01).结论 卡托普利联合胺碘酮治疗急性心肌梗死并发心房颤动疗效确切、安全,患者多方面受益,值得推广应用.

Captopril combined with amiodarone treat acute myocardial infarction complicating atrial fibrillation

Objective To approach therapeutic effect of captopril combined with amiodarone in treating acute myocardial infarction complicating atrial fibrillatio. Methods Select acute myocardial infarction complicating atrial fibrillatio 62 patients, divide into two groups, therapy bundle offer captopril combine amiodarone, control bundle offer propafenone, compare rate of atrial fibrillatio turn over with 24 houres, control rate of atrial fibrillatio attack (reduce atrial fibrillatio attacking over 60%), tetain sinus rhythn, backward heart failure incidence rate, repeated infarct rate, hospitalization death rate, death rate one year later, stroke incidence rate within one year. Results Captopril combined with amiodarone in treating acute myocardial infarction complicating atrial fibrillatio, it can turn over atrial fibrillatio utility, control atrial fibrillatio attack (reduce atrial fibrillatio attacking over 60%), reduce repeated infarct rate (6.3% vs 16.7%), death rate (9.4% vs 16.7%), backward heart failure incidence rate (9.4% vs 30.0%), stroke incidence rate (3.1% vs 13.3%)(all P<0.01). Conclusions The therapeutic effect is certain about captopril combine amiodarone in treating acute myocardial infarction complicating atrial fibrillatio. And this method is safety. The patient profit from it in many ways. It deserves generalization and application.