| 外周型苯二氮受体与中枢神经系统疾病 |
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| 引用本文： | 陈春富,刘新峰. 外周型苯二氮受体与中枢神经系统疾病[J]. 国际脑血管病杂志, 2007, 0(1) |
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| 作者姓名： | 陈春富 刘新峰 |
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| 作者单位： | 南京军区南京总医院神经内科，南京军区南京总医院神经内科 |
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| 摘 要： | 中枢神经系统内的外周型苯二氮受体(PBR)主要分布在小胶质细胞线粒体外膜,参与调控神经类固醇的合成以及神经元的凋亡过程。最近的研究表明,PBR在各种中枢神经系统疾病,如神经变性、肿瘤、炎症、脱髓鞘、脑缺血、脑创伤、癫癎和肝性脑病中表达明显上调。PBR已成为反映体内外神经病理学改变的一种敏感而特异的定量指标。深入研究PBR在中枢神经系统疾病中的作用机制,有可能为这些疾病的治疗找到一条新的途径。
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| 关 键 词： | 外周型苯二氮受体 中枢神经系统疾病 病理生理学 神经元 |
Peripheral Benzodiazepine Receptors and Central Nervous System Diseases |
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| Chun-Fu Chen,Xin-Feng Liu. Peripheral Benzodiazepine Receptors and Central Nervous System Diseases[J]. International Journal of Cerebrovascular Diseases, 2007, 0(1) |
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| Authors: | Chun-Fu Chen Xin-Feng Liu |
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| Affiliation: | Chun-Fu Chen,Xin-Feng Liu Department of Neurology,Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China |
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| Abstract: | Peripheral benzodiazepine receptors (PBRs) in central nervous system (CNS) mainly distribute on the mitochondrial outer membrane of microglial cells. They participate in regulating the synthesis of neurosteroid and the process of neuronal apoptosis. Recent researches have indicated that the expressions of PBRs increased significantly in various CNS diseases, such as neurodegeneration, glioma, inflammation, demyelination, cerebral ischemia, brain trauma, epilepsy and hepatic encephalopathy. PBRs have become a sensitive and specific qualification indicator in reflecting neuropathological changes in vitro and in vivo. Further insight into the mechanism of action of PBRs in CNS diseases may find a new approach for the treatment of these diseases. |
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| Keywords: | peripheral benzodiazepine receptor central nenous system disease pathophysiology neuron |
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