托拉塞米治疗急性脑出血84例疗效分析

目的分析托拉塞米治疗急性脑出血的疗效。方法将我院收治的84例急性脑出血患者随机分为对照组和观察组，每组42例，观察组在常规治疗的基础上给予托拉塞米联合甘露醇治疗，对照组在常规治疗的基础上给予呋塞米联合甘露醇治疗，综合治疗2周，84例患者在治疗过程中每天进行电解质与肾功能的监测，治疗结束后给予脑水肿面积评价，比较分析二组疗效。结果治疗后观察组的显效率、有效率均高于对照组，二组在治疗后的脑水肿面积都有所减小，观察组比对照组效果更明显，另外，药物治疗后观察组出现电解质紊乱不良反应的情况明显少于对照组，差异有统计学意义。结论托拉塞米联合甘露醇可有效缓解急性脑出血导致的脑水肿，迅速释放颅内压，减少甘露醇的使用量，同时不易出现不良反应。

CLINICAL EFFECT OF TORASEMIDE IN TREATMENT OF 84 CASES OF ACUTE CEREBRAL HEMORRHAGE

Objective To analyze the efficacy of Torasemide in treatment of acute cerebral hemorrhage. Methods Totally 84 cases with acute cerebral hemorrhage from October 2010 to December 2012 in au-thor＇s hospital were randomly divided into control group and observation group, 42 patients in each group. The observation group was treated with torasemide combined with mannitol treatment based on conventional treatment, the control group received furosemide and mannitol on the basis of convention-al therapy, comprehensive treatment for two weeks. Electrolytes and renal function were detected ev-ery day, cerebral edema area was evaluated after the end of treatment, then compared curative effect of two groups. Results After treatment, cerebral edema area were decreased in two groups, the efficacy in observation group was better. Markedly effective rate, effective rate of observation group were higher than that of control group. In addition, after drug treatment, observation group had adverse re- action of electrolyte disorder, it was significantly less than that of the control group, the difference had statistical significance. Conclusions Torasemide combined with mannitol can effectively alleviate cere-bral edema induced by acute cerebral hemorrhage, rapid release of intracranial pressure, reduce the use of mannitol, and is less prone to adverse reactions.