| Abstract: | Objective: To observe the effect of puerarin on superoxide dismutase (SOD), lipid peroxidation (LPO), tissue plasminogen (TPA) and
plasminogen activator inhibitor (PAI-1) of coronary heart disease (CHD) patients.Methods: Forty-eight patients were divided into two groups (treated group and control group). Treated group was given intravenously
600 mg puerarin, once daily for one week, also the same treatment as that of control was given. Nitrite colorimetric method,
radioimmunoassay (RIA), TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development
process were used to determine SOD activity, SOD, LPO, TPA and PAI-1.Results: After the treatment with puerarin, SOD activity was increased, LPO reduced, while without any changes in the control group.
There was insignificant changes of SOD between the treated and the control groups. TPA and PAI-1 were increased significantly
in the treated group, but was insignificantly changed in the control group.Conclusion: Puerarin can increase the SOD activity, decrease LPO level and enhance the activity of fibrinolysis. |
