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Patient characteristics differently affect early cup and stem loosening in THA: a case-control study on 7,535 patients
Authors:C Röder  S Eggli  P Münger  M Melloh  A Busato
Institution:(1) MEM Research Center in Orthopaedic Surgery, Institute for Evaluative Research in Orthopaedic Surgery, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland;(2) Department of Orthopaedic Surgery, Inselspital, University of Bern, 3001 Bern, Switzerland;(3) Health Technology Assessment and Clinical Epidemiology, MEM Research Center in Orthopaedic Surgery, Institute for Evaluative Research in Orthopaedic Surgery, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland
Abstract:We postulated that certain patient characteristics have different effects on early THA component loosening. With two matched case-control studies we assessed 3,028 cups and 5,224 stems. Loosening was defined using signs of mechanical component failure on routine follow-up radiographs or revision for aseptic loosening. Women and men had similar cup-loosening odds, but women had lower odds for stem loosening (p < 0.0001). Odds for cup loosening decreased by 2.1% per additional year of age (p = 0.0004), those for stem loosening by 2.4% (p < 0.0001). Each additional kilogram of weight decreased cup loosening odds by 1.3% (p = 0.0051). Each additional unit of BMI increased stem loosening odds (p = 0.0109). Charnley classes B and C were protective factors against loosening of both components. There were no risk differences for the various main diagnoses. Certain patient characteristics differently affected early cup and stem loosening, although some characteristics had the same protective or harmful effect on component survival.
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