嗜酒结核病患者用异烟肼、利福喷丁和吡嗪酰胺治疗出现严重肝损害

1名55岁有嗜酒史的男性肺结核患者，口服异烟肼0．3g／d、利福喷丁0．45g／d2次／周、吡嗪酰胺1．5g／d。3周后出现乏力、食欲不振、尿黄、皮肤巩膜黄染，并出现腹水。实验室检查：ALT 178．9U／L，AST 85．7 U／L，TBil 136．4μmol／L，DBil 134μmol／L。甲、乙、丙、丁、戊型肝炎血清学试验均呈阴性。给予保肝、对症治疗。12d后，症状好转，肝功能恢复正常。

Severe liver damage occurring with isoniazide,rifapentine,and pyrazinamide in an alcoholic patient with pulmonary tuberculosis

A 55-year-old alcoholic man with pulmonary tuberculosis received oral isoniazide 0.3 g/d, rifapentine 0, 45 g/d twice weekly, pyrazinamide 1.5 g/d, Three weeks later, the patient experienced hypodynamia, anorexia, dark urine, yellowish of skin and sclera, and ascites. I.aboratory investigations revealed the following values： ALT 178, 9 U/L, AST 85.7 U/L, TBiL 136.4 μmol/L, DBiL 134 μmol/L. Serologic tests for hepatitis A, B, C, D, and E were negative. The patient was given liver-protective and symptomatic treatment. Twelve days later, his symptoms improved and his liver function returned to normal ranges.