The novel miR-9501 inhibits cell proliferation,migration and activates apoptosis in non-small cell lung cancer |
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Authors: | Yongyong?Xi Liang?wang Chengcao?Sun Cuili?Yang Feng?Zhang Email author" target="_blank">Dejia?LiEmail author |
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Institution: | 1.Department of Occupational and Environmental Health, School of Public Health,Wuhan University,Wuhan,China |
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Abstract: | Accumulating evidences suggest that lots of microRNAs (miRNAs) play crucial roles in (patho-)physiological processes of lung cancer, including metastasis, drug-resistance or tumorigenesis. They mediate the progression of cell growth, migration and invasion by regulating the expression of special genes. MiRNA expression patterns could also serve as diagnostic/prognostic biomarkers. Cancer therapies mediated by miRNAs remain tremendous potential and challenges. Our previous small RNA-seq assay found that the novel miR-9501 was down-regulated in lung cancer tissues compared with adjacent non-cancer tissues. In this study, our results verified that miR-9501 was significantly down-regulated in lung cancer tissues and its expression levels were remarkably suppressed in non-small cell lung cancer cell lines. Then, we characterized and investigated the novel miR-9501 in A549 cells. Transient transfection of miR-9501 into cultured A549 cells led to remarkable decrease in cell proliferation, migration and increase apoptosis. These data demonstrated that miR-9501 might be a tumor suppressor for lung cancer therapy. |
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