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From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation |
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| Authors: | T.?Fulop author-information" > author-information__contact u-icon-before" > mailto:Tamas.Fulop@USherbrooke.ca" title=" Tamas.Fulop@USherbrooke.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,G.?Dupuis,S.?Baehl,A.?Le?Page,K.?Bourgade,E.?Frost,J.?M.?Witkowski,G.?Pawelec,A.?Larbi,S.?Cunnane |
| Affiliation: | 1.Immunology Programme, Division of Geriatrics, Department of Medicine, Research Center on Aging,University of Sherbrooke,Sherbrooke,Canada;2.Immunology Programme, Department of Biochemistry, Faculty of Medicine and Health Sciences,University of Sherbrooke,Sherbrooke,Canada;3.Department of Infectiology and Microbiology,University of Sherbrooke,Sherbrooke,Canada;4.Department of Pathophysiology,Medical University of Gdańsk,Gdańsk,Poland;5.Center for Medical Research,University of Tübingen,Tübingen,Germany;6.Singapore Immunology Network (SIgN), Biopolis,Agency for Science Technology and Research (A*STAR),Singapore,Singapore;7.Division of Endocrinology, Department of Medicine, Research Center on Aging,University of Sherbrooke,Sherbrooke,Canada;8.Geriatrics Division, Department of Medicine, Research Center on Aging,Université de Sherbrooke,Sherbrooke,Canada |
| Abstract: | Aging is accompanied by many physiological changes including those in the immune system. These changes are designated as immunosenescence indicating that age induces a decrease in immune functions. However, since many years we know that some aspects are not decreasing but instead are increasing like the pro-inflammatory activity by the innate immune cells, especially by monocytes/macrophages. Recently it became evident that these cells may possess a sort of memory called trained memory sustained by epigenetic changes occurring long after even in the absence of the initiator aggressor. In this review we are reviewing evidences that such changes may occur in aging and describe the relationship between inflamm-aging and immunosenescence as an adaptation/remodelling process leading on one hand to increased inflammation and on the other to decreased immune response (immune-paralysis) mastered by the innate immune system. These changes may collectively induce a state of alertness which assure an immune response even if ultimately resulting in age-related deleterious inflammatory diseases. |
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