| Affiliation: | 1.College of Chemistry and Chemical Engineering, The Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi Province,Xi’an University,Xi’an,China;2.Department of Pharmacology, School of Pharmacy,The Fourth Military Medical University,Xi’an,China;3.Department of Neurosurgery, Xijing Hospital,The Fourth Military Medical University,Xi’an,China;4.Department of Physics, School of Science,Tianjin University,Tianjin,China |
| Abstract: | A series of bisoumarin (1–4) and dihydropyran (5–8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1–4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method. |
