| Institution: | 1.Department of General Surgery,Tongren Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai,China;2.Department of Pathology,Tongren Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai,China;3.Department of General Surgery,No. 1 Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai,China |
| Abstract: | PurposeTo evaluate the effects of early-phase drainage on the survival rates and pancreatic pathological changes associated with severe acute pancreatitis (SAP) in a rat model.MethodsSprague–Dawley rats were divided into the following groups: SAP model (control), early drainage and delayed drainage. The 24-h survival rates were compared among the groups. In addition, the serum and ascites concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α were measured, and pancreatic pathological changes were observed.ResultsThe survival rate significantly improved in the early drainage group. Compared with that observed in the control group, the serum TNF-α and IL-8 concentrations in the early drainage group decreased, while the serum IL-10 levels increased, and the ascites concentrations of IL-1β, IL-6, IL-8 and TNF-α decreased, while that of IL-10 increased significantly. In the delayed drainage group, only the ascites concentrations of TNF-α decreased. Meanwhile, the pancreatic pathological changes at 3, 6 and 24 h worsened in the early drainage group; however, the pancreatic lesions in the early drainage group were less mild than those seen in the control group.ConclusionsRebalancing the cytokine levels in ascites after early drainage may be a key factor for enhancing the survival rate in rats. |
