| Affiliation: | 1.Department of Neurology,University of North Carolina,Chapel Hill,USA;2.Harvard University,Boston,USA;3.University of Washington,Seattle,USA;4.Northwestern University,Chicago,USA;5.University of Zimbabwe,Harare,Zimbabwe;6.Johns Hopkins University,Baltimore,USA;7.Fiocruz,Rio De Janeiro,Brazil;8.University of Colorado Denver,Aurora,USA;9.Frontier Science,Buffalo,USA;10.AIDS Clinical Trials Group, Division of AIDS, NIAID,National Institutes of Health,Bethesda,USA;11.Queen Elizabeth,Blantyre,Malawi;12.Chiang Mai University,Chiang Mai,Thailand;13.NARI,Pune,India;14.YRGCARE,Chennai,India;15.Asociacion Civil Impacta Salud y Educacion,Lima,Peru;16.Naval Medical Research Unit Six (NAMRU-6),Lima,Peru;17.UNC Project,Lilongwe,Malawi;18.University of the Witwatersrand,Johannesburg,South Africa;19.Social Scientific Systems,Silver Springs,USA;20.University of KwaZulu-Natal,Durban,South Africa |
| Abstract: | Infrastructure for conducting neurological research in resource-limited settings (RLS) is limited. The lack of neurological and neuropsychological (NP) assessment and normative data needed for clinical interpretation impedes research and clinical care. Here, we report on ACTG 5271, which provided neurological training of clinical site personnel and collected neurocognitive normative comparison data in diverse settings. At ten sites in seven RLS countries, we provided training for NP assessments. We collected normative comparison data on HIV? participants from Brazil (n?=?240), India (n?=?480), Malawi (n?=?481), Peru (n?=?239), South Africa (480), Thailand (n?=?240), and Zimbabwe (n?=?240). Participants had a negative HIV test within 30 days before standardized NP exams were administered at baseline and 770 at 6 months. Participants were enrolled in eight strata, gender (female and male), education (<10 and ≥10 years), and age (<35 and ≥35 years). Of 2400 enrolled, 770 completed the 6-month follow-up. As expected, significant between-country differences were evident in all the neurocognitive test scores (p?
|
