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| 塞利洛尔与阿替洛尔治疗高血压的对照研究 | |
| 引用本文： | 钱珠,王宪衍,金翠燕,朱理敏,黄体钢,吴国亭.塞利洛尔与阿替洛尔治疗高血压的对照研究[J].上海交通大学学报(医学版),2001,21(2). |
| 作者姓名： | 钱珠 王宪衍 金翠燕 朱理敏 黄体钢 吴国亭 |
| 作者单位： | 1. 上海第二医科大学瑞金医院上海市高血压研究所, 2. 天津医科大学第二医院 3. 哈尔滨医科大学临床药理基地 |
| 摘 要： | 目的观察塞利洛尔治疗原发性高血压的降压疗效并与阿替洛尔进行比较。方法采用多中心、随机、双盲、平行对照法，入选21～60岁血压为(160～200)mmHg/(95～114)mmHg(1mmHg=0.133kPa)的原发性高血压病人240例进行8周的观察，随机服用塞利洛尔100～400mg/d或阿替洛尔25～100mg/d。结果塞利洛尔组(114例)血压从(163.9±20.3)mmHg/(105±11.3)mmHg降至(139.1±17.2)mmHg/(86.0±7.3)mmHg；阿替洛尔组(112例)血压从(164.5±20.0)mmHg/(104.0±8.1)mmHg降至(138.2±17.4)mmHg/(84.2±8.3)mmHg。控制24h血压，塞利洛尔较阿替洛尔为佳。结论β受体阻滞剂塞利洛尔是一种有效而安全的降压药，比阿替洛尔有更好的控制24h血压的作用，推荐剂量为100～300mg/d。 |
| 关 键 词： | 塞利洛尔 阿替洛尔 高血压 |
The Parallel Comparative Trial of Celiprolol and Atenolol Monotherapy in Patients with Essential Hypertension |
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| Abstract: | Objective To observe the antihypertensive efficacy of celiprolol in patients with essential hypertension and compare with that of atenolol. Methods The study was a multicentre, randomized, double-blind, parallel trial of 8 weeks' duration conducted at three medical centers in China. Men and women aged 21～60 years with baseline blood pressure at (160～200)mmHg/(95～114)mmHg (1mmHg=0.133kPa) were included in the study, and randomly allocated to receive either celiprolol or atenolol. The doses were 100～400mg/d for celiprolol and 25～100mg/d for atenolol. Results Systolic and diastolic blood pressure decreased significantly from the baseline in both groups (P＜0.0001). The blood pressure was reduced from (163.9±20.3)mmHg/(105.1±11.3)mmHg to( 139.1±17.2) mmHg/(86.0±7.3) mmHg in the celiprolol group and from (164.5±20.0) mmHg/(104.0±8.1) mmHg to (138.2±17.4)mmHg/(84.2±8.3)mmHg in the atenolol group. Better control of 24h blood pressure was observed in the celiprolol group. Conclusion β-blocker celiprolol is an effective and safe antihypertensive drug. It has better 24h blood pressure control than atenolol. The recommended dosage is 100～300mg once a day with morning. |
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