肠易激综合征患者5-羟色胺含量的变化 |
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引用本文: | 张川,李定国,王彝康,陆汉明. 肠易激综合征患者5-羟色胺含量的变化[J]. 上海交通大学学报(医学版), 2001, 21(1) |
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作者姓名: | 张川 李定国 王彝康 陆汉明 |
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作者单位: | 1. 上海第二医科大学宝钢医院消化科, 2. 新华医院消化科 |
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摘 要: | 目的探讨5-羟色胺(5-HT)与肠易激综合征(irritable bowel syndrome,IBS)发病的关系。方法应用荧光分光光度法测定IBS患者和对照组血清5HT、游离色氨酸(TP)和总TP含量。应用高效液相色谱仪测定乙状结肠粘膜中2-HT的含量。结果与对照组比较,腹泻型血清5-HT浓度(496.27±128.22ng/ml)显著升高(P<0.05)。两种类型乙状结肠粘膜5-HT含量(1877 67±655.00ng/g,1899.55±817.89ng/g)均显著高于对照组(1202.69±512.69ng/g)(P<0.05)。结论5-HT浓度升高可能与IBS发病有关;IBS患者5-HT含量升高与血清中总TP或游离TP浓度无关。
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关 键 词: | 肠易激综合症 5-羟色胺 色氨酸 |
The Alteration of 5-Hydroxytryptamine Content in the Patients with Irritable Bowel Syndrome |
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Abstract: | Objective To study the relationship between 5-hydroxytryptamine (5-HT) andthe patients with irritable bowel syndrome (IBS). Methods The contents of free tryptophan (TP), to-tal TP, 5-HT in serum and 5-HT in sigrnoid colon mucosa specimens were detected by spectrofluo-rophotometry and high-performance liquid chromatograph (HPLC) with thin-layer electrochemical(EC) detection method in patients with irritable bowel syndrome (IBS) and healthy volunteers.Results The concentrations of 5-HT in the serum of diarrhea-predominant IBS, the contents of 5-HT in both diarrhea-predominant IBS and constipation-predominant IBS in sigmoid colon mucosa weresignificantly higher; the concentrations of free and total TP were similar to those of the control group.Conclusion The results suggest that higher level of 5-HT may be involved in the pathogenic mecha-nism. The results also suggest that the increased content of 5-HT in the patients with IBS is not relatedto total and free TP in serum. |
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