| P53和C-erbB-2过表达与乳腺癌预后的关系 |
| |
| 引用本文： | 浦勇顺,周金良,王芳. P53和C-erbB-2过表达与乳腺癌预后的关系[J]. 上海交通大学学报(医学版), 2001, 21(2) |
| |
| 作者姓名： | 浦勇顺 周金良 王芳 |
| |
| 作者单位： | 1. 上海市杨浦区妇幼保健院乳腺外科,
2. 上海市长宁区中心医院病理科 |
| |
| 摘 要： | 目的探讨用癌基因和抑癌基因蛋白产物的过表达与乳腺癌预后的关系。方法应用免疫组化s-P法检查48例乳腺癌中抑癌基因(P53)，原癌基因(C-erbB-2)，增殖细胞抗原(PCNA)和雌激素受体(ER)表达水平。结果 48例乳腺癌中P53，C-erbB-2，PCNA和ER阳性表达率分别为54％，43％，52％和41.6％。P53，C-erbB-2随组织分级增高呈递增趋势，Ⅰ级与Ⅱ、Ⅲ级间阳性率差异显著(P＜0.05)，伴有淋巴结转移组与无淋巴结转移组间也存在显著差异(P＜0.05)。结论 P53，C-erbB-2过表达可以作为判断预后的指标。
|
| 关 键 词： | P53 C-erbB-2 乳腺癌 |
Effect of over Expression of P53 and C-erbB-2 on Prognosis of Breast Cancer |
| |
| PU Yong-shun,ZHOU Jin-liang,WANG Fang. Effect of over Expression of P53 and C-erbB-2 on Prognosis of Breast Cancer[J]. Journal of Shanghai Jiaotong University:Medical Science, 2001, 21(2) |
| |
| Authors: | PU Yong-shun ZHOU Jin-liang WANG Fang |
| |
| Abstract: | Objective The purpose of this study is to assess the prognostic significance of over expression of P53, C-erbB-2 in breast cancer. Methods In 48 patients with breast cancer the expression of P53, C-erbB-2, PCNA and ER was determined by the S-P staining immunohistochemical technique. Results The positive rate of P53, C-erbB-2, PCNA and ER were 54％, 43.7％ 52％, 41.6％ seperateiy. Expression of P53 and C-erbB-2 increased with the class of the tissuess. There is significant difference between grade Ⅰ and Ⅱ , Ⅲ (P＜0.05) as well as between lymph node metastasis (＋) and lymph node metastasis (-) patients (P＜0.05). Conclusion The over expression of P53, C-erbB-2 may be a useful prognostic indicator in breast cancer. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
|
