β2-Adrenergic Receptor Polymorphisms Affect Airway Responsiveness to Salbutamol in Asthmatics |
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Authors: | Yoshikazu Kotani Yoshihiro Nishimura Hitoshi Maeda Mitsuhiro Yokoyama |
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Affiliation: | a First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan |
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Abstract: | We examined the β-adrenergic receptor (β2AR) polymorphisms (Arg16 → Gly, Gln27 → Glu) and clinical status for 117 asthmatics. Airway responsiveness to methacholine and β2-agonists was evaluated with Astograph®. The atopic factors, pulmonary function test, and airway responsiveness to methacholine did not differ significantly among the different β2AR genotypes. Asthmatics homozygous for Glyl 6 showed significantly lower airway responsiveness to inhaled salbutamol than those heterozygous for Arg/Gly16 or homozygous for Arg16. Asthmatics heterozygous for Gln/Glu27 had significantly later asthma onsets than those homozygous for Gln27. These results suggest that β2AR polymorphisms play an important role in the airway responsiveness to inhaled β2- agonist and the initial asthma onset. |
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Keywords: | Bronchial asthma β-Adrenergic receptor gene Onset Airway responsiveness |
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