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Interferon treatment on glomerulonephritis associated with hepatitis C virus |
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| Authors: | Sayuri Matsumoto S. Nakajima Kana Nakamura Yuri Etani Haruhiko Hirai Nobuhiko Shimizu Hitoshi Yokoyama Yasushi Kobayashi Hitoshi Tajiri Masaaki Shima Shintaro Okada |
| Affiliation: | (1) Department of Pediatrics, D-5, Developmental Medicine, Osaka University Graduate School of Medical Science, Suita, Osaka, 565-0871, Japan e-mail: nakajima@ped.med.osaka-u.ac.jp Tel.: +81-6-68793932, Fax: +81-6-68793939, JP;(2) Division of Blood Purification, School of Medicine, Kanazawa University, Kanazawa, Japan, JP;(3) Department of Pathology, Osaka Kosei-Nenkin Hospital, Osaka, Japan, JP |
| Abstract: | We report on a 10-year-old girl with glomerulonephritis associated with hepatitis C virus infection, who was treated with interferon-α. On the first renal biopsy at 8 years of age, mild mesangial hypercellularity in a segmental to semiglobal pattern was present in all glomeruli. After 6 months interferon-α therapy, proteinuria diminished completely. However, mesangial proliferation was advanced on the second biopsy at 10 years of age. We concluded that the interferon-α was effective in the treatment of proteinuria despite the lack of pathological improvement. Received: 15 March 2000 / Revised: 11 July 2000 / Accepted: 14 July 2000 |
| Keywords: | Hepatitis C virus Mesangial proliferative glomerulonephritis Interferon-α |
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