| 阿得福韦酯治疗慢性乙型肝炎的临床观察 |
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| 引用本文： | 柴艳峰. 阿得福韦酯治疗慢性乙型肝炎的临床观察[J]. 实用全科医学, 2008, 6(5): 489-490 |
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| 作者姓名： | 柴艳峰 |
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| 作者单位： | 山东省苍山县人民医院感染科,277700 |
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| 摘 要： | 目的探讨阿得福韦酯治疗慢性乙型肝炎时患者血清纤维化指标的影响。方法时60例慢性乙型肝炎患者阿得福韦酯治疗前和治疗1年后血清透明质酸（HA）、层粘蛋白（LN）Ⅲ前胶原（PcⅢ）和Ⅳ型胶原（Ⅳc）测定水平进行检测。结果治疗组血清肝纤维化指标有明显下降（P〈0．01），与时照组比较差异有统计学意义（P〈0．01）。结论慢性乙型肝炎经阿得福韦酯治疗1年后肝纤维化指标有明显降低。
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| 关 键 词： | 慢性乙型肝炎 阿得福韦酯 肝纤维化 |
| 文章编号： | 1672-1764(2008)05-0489-02 |
| 修稿时间： | 2007-11-19 |
Clinical Effect of Adefovir Dipivoxil for Chronic Hepatitis B |
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| CHAI Yan-feng. Clinical Effect of Adefovir Dipivoxil for Chronic Hepatitis B[J]. Applied Journal Of General Practice, 2008, 6(5): 489-490 |
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| Authors: | CHAI Yan-feng |
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| Affiliation: | CHAI Yan-feng( Department of Infection, People＇ s Hospital of Cangshan County,Shandong 277700, China ) |
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| Abstract: | Objective To investigate the affection of Adefovir dipivoxil on the serum fibrosis marks in patients with chronic hepatitis B. Methods 120 patients with chronic hepatitis B were randomly divided into treatment group and control group. The treatment group （ n = 60 ） was treated with Adefovir dipivoxil. The levels of serum hyaluronic acid （ HA ）, laminin （ LN ）, type Ⅲ procollagen （ Pc Ⅲ ）, type Ⅳ collagen （ Ⅳ c ） of each group were detected before treatment and after 1 year of treatment. Results The level of serum HA, IN, pC Ⅲ and Ivc significantly decreased after the treatment of Adefovir dipivoxil （P 〈 0.01 ）. The level of each indexes of the treatment groups was obviously different from that of the control group after the treatment （ P 〈 0.01 ）. Conclusions Adefovir dipivoxil could obviously decreasethe serum hepatic fibrosis index in patients with chromic hepatitis B. |
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| Keywords: | Chronic hepatitis B Adefovir dipivoxil Hepatic fibrosis |
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