胰岛素样生长因子-Ⅰ及其受体在胃癌的表达和意义

目的 探讨胰岛素样生长因子Ⅰ（IGF—Ⅰ）及其受体（IGF—IR）在胃癌的表达情况及临床意义。方法应用免疫组化方法检测40例原发性胃癌组织及其远端正常胃黏膜中IGF—Ⅰ和IGF—IR的表达，并分析其表达与胃癌病理分级、临床分期、淋巴结转移、肿瘤侵袭深度的关系。结果胃癌组织IGF—Ⅰ和IGF—IR表达的阳性率分别为80％、77．5％，均显著高于远端正常胃黏膜的阳性率27．5％、25％（P〈0．005）。IGF—Ⅰ和1GF—IR的表达与性别、年龄、分化程度无关（P〉0．05）；TNM分期Ⅲ＋Ⅳ期胃癌组织的IGF—Ⅰ和IGF—IR蛋白表达水平均高于Ⅰ＋Ⅱ期（P〈0．05）；伴有淋巴结转移胃癌组织中的表达明显高于不伴有淋巴结转移者（P〈0．05）。IGF—Ⅰ和IGF—IR在胃癌组织中的蛋白表达水平呈正相关（rs=0．5824，P〈0．001）。结论IGF—Ⅰ和IGF-IR在胃癌组织中蛋白表达水平与胃癌TNM分期、转移能力有关，提示IGF—Ⅰ和IGF—IR的高表达在胃癌的发展过程中起了重要作用。

The expression and significance of IGF- I and its receptor in human gastric cancer

Objective To explore the expression and significance of insulin-like growth factor-Ⅰ （IGF-Ⅰ） and （IGF- Ⅰ R） in human gastric cancer. Methods We analyzed the expression of IGF- Ⅰ and IGF- I R in 40 paired samples of tumor-free tissues and carcinomatous gastric tissues by immunohistochemistry. The relationship of expression of IGF- Ⅰ and IGF- Ⅰ R with various clinicopathological parameters were analyzed. Results As measured by immunohistochemistry, the positive rates of IGF- Ⅰ and IGF- Ⅰ R expressions in tumor tissues were 80% and 77.5%, significantly higher than that of 27.5% and 25% in tumor-free tissues, respectively （P 〈 0. 005）. No correlation were found between expression levels of IGF- Ⅰ/IGF- Ⅰ R and differentiation of patients sex, age, histology （P 〉 0.05 ）. The IGF- Ⅰ and IGF- ⅠR protein expressions were higher in stage Ⅲ＋ Ⅳ of gastric cancer than that in stage Ⅰ ＋Ⅱ of gastric cancer, and were higher in gastric cancer with lymphnode metastasis than that in those without lymphnode metastasis （P 〈 0.05）. There was a positive correlation between the overexpression of IGF- Ⅰ and IGF- Ⅰ R in the gastric cancer. Conclusion The over expression of IGF- Ⅰ/IGF- Ⅰ R in gastric cancer is correlated with the TNM stage and the metastasis. Our results suggest that IGF- Ⅰ/IGF- Ⅰ R plays an important role in the pathogenesis of gastric cancer.