咳喘穴位贴片透皮促进剂用量的筛选

目的:优选咳喘穴位贴片透皮促进剂——氮酮的最佳用量。方法:以丁香酚累积渗透百分率为评价指标,用离体兔皮及Franz扩散池进行体外透皮试验,考察氮酮用量分别为0%、1%、3%的透皮速率及透皮总量,建立透皮动力学模型,提取并比较透皮特性参数。结果:加0%、1%氮酮的药物透皮动力学模型为Higuchi模型;加3%氮酮的药物透皮动力学模型为威布尔模型。加1%氮酮透皮速度最快,是未加氮酮的5.019倍;累积透皮总量最多,是未加氮酮的2.489倍。结论:氮酮用量为1%时透皮速度最快,透皮量最大。

Screening Study on Penetration Enhancers of Kechuanxuewei Patch

OBJECTIVE:To explore the optimal concentration of the penetration enhancers-laurocapam(Azone)for Kechuanxuewei patch,and to screen the best technological conditions.METHODS:Using the cumulative permeation percentage of Eugend as assessment parameter,an in vitro transdermal test was performed on the extracorporeal rabbit skin in a special improved Franz(one-compartment)diffusion cell to identify the penetration speed and permeation of Azone at the amounts of 0%,1% and 3%.A transdermal dynamics model was established to extract skin penetration parameters and compare the indexes.RESULTS:The dynamics model of penetration rabbit skin rate meets Higuchi equation through mathematic disposal treatment and statistical analysis,when the amounts of Azone were at 0% and 1% ;the model was in line with the Weibull distribution model when the amount of Azone was at 3%.When 1% Azone was added,the test showed the fastest speed in skin penetration,5.019 times that without Azone,and generated the most penetration concentration,2.489 times that without Azone.CONCLUSION:When 1% Azone was added,the test showed the fastest speed in skin penetration and generated the most penetration concentration.