High incidence of Down's syndrome in infants of diabetic mothers |
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Authors: | H Narchi N Kulaylat |
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Institution: | Al-Hasa Specialty Services Division, Saudi Aramco-Al-Hasa Health Center, Saudi Aramco Medical Services Organization, Mubarraz, Kingdom of Saudi Arabia. |
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Abstract: |
The incidence of Down''s syndrome was studied in 1870 infants
of diabetic mothers out of 22 300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for
diabetes and all cases of Down''s syndrome were confirmed by chromosome analysis. Down''s syndrome (all trisomy 21) was diagnosed in 35 infants:
seven were born to mothers with gestational diabetes and 28to
non-diabetic mothers. The incidence of Down''s syndrome was higher in
infants of diabetic mothers (3.75 per 1000 v 1.36 per 1000) (p= 0.02) with a relative risk of 2.75. No significant difference was found in maternal age between both groups (p= 0.67) and the rate of
Down''s syndrome was higher in infants of diabetic mothers when
compared with infants of non-diabetic mothers of similar age. Down''s syndrome should be added to the congenital
malformations already known to occur more frequently in infants of
diabetic mothers.
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