| 一氧化氮对伤段脊髓兴奋性氨基酸含量动态变化的影响及其意义 |
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| 引用本文： | 周初松,靳安民,张辉.一氧化氮对伤段脊髓兴奋性氨基酸含量动态变化的影响及其意义[J].中国矫形外科杂志,1999(7). |
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| 作者姓名： | 周初松 靳安民 张辉 |
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| 作者单位： | 第一军医大学附属珠江医院全军骨科中心 |
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| 摘 要： | 目的：为了探讨一氧化氮（ＮＯ）在继发性脊髓损伤中的作用机制。方法：本实验通过微透析技术及反相高效液相色谱荧光法动态地观测了ＮＯ对急性脊髓压迫伤后伤段脊髓局部兴奋性氨基酸（ＥＡＡ）含量动态变化的影响。结果：脊髓伤前３０ｍｉｎ蛛网膜下腔注射左旋精氨酸（ＬＡｒｇ）明显升高了伤段脊髓组织谷氨酸（ＧＬＵ）及天门冬氨酸（ＡＳＰ）的浓度，而蛛网膜下腔注射亚硝基左旋精氨酸甲酯（ＬＮＡＭＥ）则降低了其上升的幅度。结论：急性脊髓损伤早期ＮＯ的产生能促进ＥＡＡ的释放，从而加重继发性脊髓损伤。
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| 关 键 词： | 脊髓损伤 一氧化氮 兴奋性氨基酸 微透析 |
Effect of Nitric Oxide on Dynamical Changes of Excitatory Amino Acids in Injuried Spinal Cord
and Its Significance |
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| Zhou Chusong,Jin Anmin,Zhang Hui.Effect of Nitric Oxide on Dynamical Changes of Excitatory Amino Acids in Injuried Spinal Cord
and Its Significance[J].The Orthopedic Journal of China,1999(7). |
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| Authors: | Zhou Chusong Jin Anmin Zhang Hui |
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| Institution: | Zhou Chusong,Jin Anmin,Zhang Hui.Department of
Orthopedics,Zhujiang Hospital,The First Military Medical University,Guangzhou 510282. |
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| Abstract: | Objective:To investigate the mechanism of effect of nitric oxide (NO) on secondary
spinal cord injury.Methods:This experiment dynamically measured the effect of NO on content
change of excitatory amino acid(EAA) after acute spinal cord compression by microdialysis and
rHPLC.Results:The concentration of glutamate (GLU) and aspartate(ASP) in injured spinal cord
increased significantly after Larginine(LArg) was infused into the spinal subarachnoid space at
30 min before injury;but lowered after NniroLarginine methyl ester(LNAME)was
infused.Conclusion:NO can promote EAA release and worsen secondary spinal cord injury |
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| Keywords: | Spinal cord injuryNitric oxideExcitatory amino acidMicrodialysis |
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