| 基因多态性与骨密度的相关性 |
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| 引用本文： | 陈玲,樊继援. 基因多态性与骨密度的相关性[J]. 国际内分泌代谢杂志, 2008, 28(4) |
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| 作者姓名： | 陈玲 樊继援 |
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| 作者单位： | 天津医科大学总医院内分泌科,300052;天津医科大学总医院内分泌科,300052 |
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| 摘 要： | 骨密度受遗传因素影响,骨密度测定是诊断骨质疏松的主要依据.维生素D受体、Ⅰ型胶原、雌激素受体、降钙素受体参与骨形成和骨代谢,其基因多态性决定骨密度.研究发现Wnt蛋白、人类白细胞抗原等基因多态性也与骨密度有关.本文就基因多态性与骨密度的相关性进行论述.
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| 关 键 词： | 骨密度 骨质疏松 基因多态性 |
Association between gene polymorphism and bone mineral density |
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| CHEN Ling,FAN Ji-yuan. Association between gene polymorphism and bone mineral density[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(4) |
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| Authors: | CHEN Ling FAN Ji-yuan |
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| Abstract: | Bone mineral density is related with heritage.Diagnosis of osteoporosis mostly depends on the detection of bone mineral density.Genes involve in bone development and bone metabolism such as vitamin D receptor,COL1,estrogen receptor and ealeitonin receptor,gene polymorphism of which determines bone minemal density.Otherwise.related genes such as Wnt protein and HLA are also related to bone mineral density.This review discusses the correlation between bone density and gene polymorphism. |
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| Keywords: | Osteooorosis Bone mineral density Gene polymorphism |
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